Journal article
The Impact of Mouthwash on the Oropharyngeal Microbiota of Men Who Have Sex with Men: a Substudy of the OMEGA Trial
EL Plummer, K Maddaford, GL Murray, CK Fairley, S Pasricha, A Mu, CS Bradshaw, DA Williamson, EPF Chow
Microbiology Spectrum | Published : 2022
Abstract
Mouthwash is a commonly used product and has been proposed as an alternative intervention to prevent gonorrhea transmission. However, the long-term effects of mouthwash on the oral microbiota are largely unknown. We investigated the impact of 12 weeks of daily mouthwash use on the oropharyngeal microbiota in a subset of men who have sex with men who participated in a randomized trial comparing the efficacy of two alcohol-free mouthwashes for the prevention of gonorrhea. We characterized the oropharyngeal microbiota using 16S rRNA gene sequencing of tonsillar fossae samples collected before and after 12 weeks of daily use of Listerine mouthwash or Biotène dry mouth oral rinse. Permutational m..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was funded by a project grant from the Australian National Health and Medical Research Council (NHMRC; GNT1122514). E.P.F.C. and D.A.W. are supported by an Australian NHMRC Emerging Leadership Investigator Grants (GNT1172873 and GNT1174555, respectively). C.K.F. and C.S.B. are supported by Australian NHMRC Leadership Investigator Grants (GNT1172900 and GNT1173361, respectively). A.M. is supported by a NOMIS Foundation Fellowship. We thank study participants and staff at the Melbourne Sexual Health Centre recruitment site: Sandra Walker, Tiffany Phillips, Alison Clough, Lucy Beaton, Sabrina Trumpour, Mark Chung, Afrizal Afrizal, Jun kit Sze, Ria Fortune, Trish Wakefield, Suzanne Amisano, Helen Henzell, Karen Berzins, Stephen Rowles, Anna Morton, Mark Thompson, Caroline Cittarelli, Surbhi Bird, Luke Mitchell, Susan Rose, and Lauren Bryar. We thank Nicole Isles from Doherty Applied Microbial Genomics for technical support.